Pisiferdiol and pisiferic acid isolated from Chamaecyparis pisifera activate protein phosphatase 2C in vitro and induce caspase-3/7-dependent apoptosis via dephosphorylation of Bad in HL60 cells.

doi:10.1016/j.phymed.2009.12.015

Paper

Pisiferdiol and pisiferic acid isolated from Chamaecyparis pisifera activate protein phosphatase 2C in vitro and induce caspase-3/7-dependent apoptosis via dephosphorylation of Bad in HL60 cells.

Published Aug 1, 2010 · N. Aburai, M. Yoshida, M. Ohnishi

Phytomedicine : international journal of phytotherapy and phytopharmacology

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22

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Abstract

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In Vitro Study

Study Snapshot

Pisiferdiol and pisiferic acid from Chamaecyparis pisifera are novel PP2C activators, with pisiferdiol showing more specific activation and inducing caspase-3/7-dependent apoptosis in HL

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Pisiferdiol and pisiferic acid isolated from Chamaecyparis pisifera activate protein phosphatase 2C in vitro and induce caspase-3/7-dependent apoptosis via dephosphorylation of Bad in HL60 cells.

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