Cytoplasmic PABP [poly(A)-binding protein] is a multifunctional protein with well-studied roles in mRNA translation and stability. In the present review, we examine recent evidence that the activity of PABP is altered during infection with a wide range of viruses, bringing about changes in its stability, complex formation and intracellular localization. Targeting of PABP by both RNA and DNA viruses highlights the role of PABP as a central regulator of gene expression.

PABP is a common viral target, altering its activity, stability, complex formation, and intracellular localization during various viral infections, highlighting its central role in gene expression regulation.

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Poly(A)-binding protein (PABP): a common viral target.

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