Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.

doi:10.1016/j.bmcl.2008.01.075

Paper

Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.

Published Mar 1, 2008 · G. R. Ott, N. Asakawa, Zhonghui Lu

Bioorganic & medicinal chemistry letters

Q2 SJR score

42

Citations

1

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Study Snapshot

Novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamides are potent, selective, and orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE).

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.

Sign up to use Study Snapshot

References

Citations

Ectodomain shedding by ADAM17 (a disintegrin and metalloproteinase 17) in canine neutrophils.

ADAM17 expression and sheddase activity are present in dogs, providing a potential therapeutic target for various inflammatory disorders.

Ectodomain shedding of L-selectin by ADAM17 in canine neutrophils

ADAM17 is a primary sheddase of canine L-selectin, which may serve as a therapeutic target to prevent neutrophil dysfunction during excessive inflammation, such as sepsis.

Ansamycin derivatives from the marine-derived Streptomyces sp. SCSGAA 0027 and their cytotoxic and antiviral activities.

Marine-derived Streptomyces sp. SCSGAA 0027 produces novel ansamycin derivatives with mild cytotoxicity against cancer cells and moderate anti-HSV-1 activity.

Iodine-mediated aminosulfonylation of alkenyl sulfonamides with sulfonyl hydrazides: synthesis of sulfonylmethyl piperidines, pyrrolidines and pyrazolines.

This study demonstrates a novel method for synthesis of sulfonylmethyl piperidines, pyrrolidines, and pyrazolines using iodine, TBHP, and sulfonyl hydrazides.

Enantioselective, Organocatalytic, Dissymmetric 1,4- and 1,2-Addition of Malononitrile to a Keto-bisenone Followed by an Oxa-Michael Addition Cascade.

This study developed an efficient organocatalytic method for enantioselective dissymmetric 1,4- and 1,2-addition of malononitrile to keto-bisenone followed by an oxa-Michael addition cascade, providing oxa-spiro-