Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring.

doi:10.1016/j.bioorg.2020.103755

Paper

Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring.

Published Mar 13, 2020 · R. Álvarez, Laura Aramburu, C. Gajate

Bioorganic chemistry

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12

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Abstract

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In Vitro Study

Study Snapshot

A 2-methoxy-6-methylsulfanylpyridine moiety is a promising trimethoxyphenyl ring replacement for developing new colchicine site ligands with improved intrinsic solubility and anti-proliferative effects against sensitive human cancer cell lines.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring.

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References

Citations

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POCl3 mediated one-pot deoxygenative aromatization and electrophilic chlorination of dihydroxy-2-methyl-4-oxo-indeno[1,2-b]pyrroles

POCl3-mediated one-pot deoxygenative aromatization and electrophilic chlorination of dihydroxy-2-methyl-4-oxo-indeno[1,2-b]pyrroles leads to diverse 4-oxoindeno[1,2-b]pyrrole derivatives in 58

Potent and Selective Benzothiazole-Based Antimitotics with Improved Water Solubility: Design, Synthesis, and Evaluation as Novel Anticancer Agents

Benzothiazole-based antimitotics with improved water solubility show potent and selective anticancer activity against various human cancer cell lines.

Synthesis of Isoxazole-5(4H)-ones Using Citrazinic Acid as an Organocatalyst in Aqueous Conditions

Citrazinic acid can be used as an organocatalyst for the synthesis of isoxazole-5(4H)-ones, which have diverse biological properties and potential applications in nonlinear optical materials, filter dyes, and solar cells.