Therapeutic Potential and Anti-Amyloidosis Mechanisms of Tert-Butylhydroquinone for Alzheimer's Disease

doi:10.1016/J.FREERADBIOMED.2011.10.413

Paper

Therapeutic Potential and Anti-Amyloidosis Mechanisms of Tert-Butylhydroquinone for Alzheimer's Disease

Published Nov 1, 2011 · Rui-ming Liu, H. Akhter, Ling Li

Free Radical Biology and Medicine

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Abstract

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Study Snapshot

Tert-Butylhydroquinone (TBHQ) shows potential therapeutic potential for Alzheimer's disease, with potential anti-amyloidosis mechanisms and potential for use in food and cosmetic products.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Therapeutic Potential and Anti-Amyloidosis Mechanisms of Tert-Butylhydroquinone for Alzheimer's Disease

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References

Citations

PERK Pathway and Neurodegenerative Disease: To Inhibit or to Activate?

Activating or inhibiting the PERK pathway in neurodegenerative diseases remains unclear, but strategies focusing on boosting certain steps without compromising downstream recovery show promise.

Sequential Upregulation of Superoxide Dismutase 2 and Heme Oxygenase 1 by tert-Butylhydroquinone Protects Mitochondria during Oxidative Stress

Tert-butylhydroquinone (tBHQ) protects mitochondrial function during oxidative stress by sequentially increasing SOD2 and HO-1 expression in neurons.

The effect of chronic tBHQ treatment on high salt-induced hypertension is reported • Chronic tBHQ supplementation attenuates hypertension and sympathoexcitation • Chronic tBHQ supplementation attenuates PVN oxidative stress and inflammation

Chronic tBHQ supplementation effectively reduces high salt-induced hypertension and sympathoexcitation by inhibiting hypothalamic paraventricular nucleus oxidative stress and inflammation.