Paper
Pregabalin-induced sexual disinhibition
Published Mar 8, 2017 · R. Murphy, D. McGuinness, B. Hallahan
Irish Journal of Psychological Medicine
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Abstract
Introduction Sexual side effects have rarely been reported secondary to treatment with Pregabalin, a structural analogue of the inhibitory neurotransmitter gamma amino butyric acid (GABA). Method We present the case of AB, a 27-year-old single man with a diagnosis of recurrent depressive disorder who was prescribed pregabalin to alleviate the significant anxiety symptoms he was experiencing. Results A significant amelioration in anxiety symptoms was attained; however, he developed the adverse effects of acute sexual disinhibition and increased libido. These adverse effects were temporally related to treatment with pregabalin and reduced with dose reduction of this agent. Conclusions To date, limited published data are available relating such a reaction to pregabalin. A greater clinical recognition of this association between pregabalin and sexual disinhibition, would allow clinicians to intervene at an earlier stage of this adverse effect and potentially as in this case, management may only require dose reduction rather than treatment discontinuation.
Case ReportPregabalin treatment can reduce anxiety symptoms, but may cause sexual disinhibition and increased libido, which can be managed with dose reduction rather than discontinuation.
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