A practical and simple synthesis of 2,5-disubstituted oxazoles was developed via an iodine-catalyzed tandem oxidative cyclization. A wide range of common commercial aromatic aldehydes can be used as reaction substrates, which displayed excellent functional group compatibility in this reaction.

This study developed a simple, efficient synthesis of 2,5-disubstituted oxazoles using iodine-catalyzed tandem oxidative cyclization, enabling the use of various commercial aromatic aldehydes as reaction substrates.

Paper

Simple and efficient preparation of 2,5-disubstituted oxazoles via a metal-free-catalyzed cascade cyclization.

References

Citations