The preparation of 3-Aminoxy-1-amino[1,1′-3H2]propane

doi:10.1002/JLCR.2580270206

Paper

The preparation of 3-Aminoxy-1-amino[1,1′-3H2]propane

Published Feb 1, 1989 · M. Pankaskie, Stephen J. Scholtz

Journal of Labelled Compounds and Radiopharmaceuticals

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Abstract

3-Aminoxy-1-aminopropane (APA) has previously been shown to be a potent inhibitor of the polyamine biosynthesis enzymes ornithine decarboxylase, adenosylmethionine decarboxylase, and spermidine synthase. Little information is known, however, regarding its mechanism of action, binding site mode(s), or cellular distribution. This report presents a relatively simple three step synthesis of 3-aminoxy-1-amino[1,1′-3H2]propane via the catalytic tritiation of 3-aminoxypropionitrile hydrochloride. The latter compound has previously been described in the literature, albeit in little detail, but is included in this report for continuity.

Study Snapshot

This study presents a simple three-step synthesis of 3-aminoxy-1-amino[1,1′-3H2]propane, a potent inhibitor of polyamine biosynthesis enzymes, with potential applications in drug discovery and pharmacological research.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

The preparation of 3-Aminoxy-1-amino[1,1′-3H2]propane

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References

1-Aminooxy-3-aminopropane, a new and potent inhibitor of polyamine biosynthesis that inhibits ornithine decarboxylase, adenosylmethionine decarboxylase and spermidine synthase.

1-Aminooxy-3-aminopropane is a potent inhibitor of polyamine biosynthesis, inhibiting ornithine decarboxylase, adenosylmethionine decarboxylase, and spermidine synthase, potentially being a potential

Citations

Weisell Structure and Function of Charge Deficient Polyamines The Latest Generation of Isosteric Charge Deficient Spermine Analogues

SpmTrien, a novel charge deficient spermine analogue, shows potential as a functional chemical tool for studying the role of charged amines in polyamine-dependent biological processes.