Preparation of 7,8-dimethoxy-3,4-dihydroisoquinoline, facile route to 7,8-dioxygenated-3,4-dihydroisoquinolines.

doi:10.1002/JPS.2600731137

Paper

Preparation of 7,8-dimethoxy-3,4-dihydroisoquinoline, facile route to 7,8-dioxygenated-3,4-dihydroisoquinolines.

Published Nov 1, 1984 · A. El-Fishawy, D. Slatkin, J. Knapp

Journal of pharmaceutical sciences

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2

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Abstract

Oxidation of 7,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline with potassium permanganate in acetone afforded 7,8-dimethoxy-3,4-dihydroisoquinoline as the primary product. Hence, oxidation of the appropriate secondary nonphenolic 7,8-dioxygenated tetrahydroisoquinoline alkaloid is thus a facile method for the generation of the corresponding imine. The imine is not easily prepared via the usual synthetic route involving ring closure of beta-phenethylamine derivatives.

Study Snapshot

Oxidation of 7,8-dimethoxy-3,4-dihydroisoquinoline with potassium permanganate in acetone is a facile method for generating the corresponding imine, making it a promising synthetic route for generating novel antibacterial agents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Preparation of 7,8-dimethoxy-3,4-dihydroisoquinoline, facile route to 7,8-dioxygenated-3,4-dihydroisoquinolines.

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References

Alkaloids of thalictrum—XXIII

Four new aporphine-ben-zylisoquinoline dimers have been proposed, related to fetidine, thalilutidine, and thalilutine.

The isoquinoline alkaloids

Isoquinoline alkaloids have diverse structures, syntheses, and pharmacological properties, with potential applications in medicine and biogenesis.

Alkaloids of Thalictrum. X. Two new alkaloids from T. minus var. adiantifolium: noroxyhydrastinine and thalifoline.

Two new isoquinolone alkaloids, noroxyhydrastinine (I) and thalifoline (II), have been identified in Thalictrum minus var. adiantifolium.

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