Paper
Preparation of ethyl 5(s),6-epoxy-3(r)-(methoxymethoxy)hexanoate: a key chiral intermediate for mevinolin and compactin.
Published 1985 · Y. Guindon, C. Yoakim, M. Bernstein
Tetrahedron Letters
Q3 SJR score
38
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
Ethyl 5(S),6-Epoxy-3(R)-(methoxymethoxy)hexanoate is a key chiral intermediate for Mevinolin and Compactin, which can be synthesized by dimethylboron bromide.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
···
···
···
···
Citations
Pursuing effective Gram-negative antibiotics: The chemical synthesis of negamycin
Negamycin shows promising bioactivity against Gram-negative bacteria and a novel mechanism of action, making it an intriguing lead compound for medicinal development.
2018·6citations·Lili Zhu et al.·Tetrahedron Letters
Tetrahedron Letters
Towards a Total Synthesis of Phenalinolactone Core Diterpenoid 6: Synthesis of a Racemic Decahydrobenzocyclobutaisobenzofuran with a trans‐anti‐cis Junction of the Isocyclic Rings
The study successfully synthesized a racemic decahydrobenzocyclobutaisobenzofuran with a trans-anti-cis junction, potentially leading to the target structure 5 in future work.
2017·4citations·T. Hampel et al.·European Journal of Organic Chemistry
European Journal of Organic Chemistry
Co-catalyzed two-stereocentered hydrolytic kinetic resolution: application to the synthesis of yashabushidiols A and B and the lactone unit of compactin and mevinolin
This study presents a short, efficient, and enantioselective synthesis of yashabushidiols A and B and the lactone unit of compactin and mevinolin using commercially available materials.
2015·7citations·Sunita K. Gadakh et al.·Tetrahedron-asymmetry
Tetrahedron-asymmetry
Synthesis, conformation and biology of naphthoxylosides.
All three hydroxyl groups in XylNap are essential for priming glycosaminoglycan chains and selective toxicity against tumor cells.
2011·25citations·Anna Siegbahn et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry
Total synthesis of phorboxazole B.
This study successfully synthesized phorboxazole B, a potent antitumor agent, using a highly efficient synthetic strategy involving substrate-controlled hydrogenation, iterative crotyl addition, Hg(OAc)2/I2-induced cyclization, 1,3-asymmetric induction in
2006·60citations·D. Li et al.·Chemistry
Chemistry
Toward the total synthesis of phorboxazole B: an efficient synthesis of the C20-C46 segment.
The efficient synthesis of the C20-C46 segment of phorboxazole B involves Hg(OAc)(2)/I(2)-induced cyclization, metalated 2-methyloxazole 7 coupling with lactone 6, and Julia olefination for the conjugated diene moiety.
2004·17citations·D. Li et al.·Organic letters
Organic letters
Organocopper Reagents: Substitution, Conjugate Addition, Carbo/Metallocupration, and Other Reactions
Organocopper complexes, particularly those derived from copper(I) cyanide, are essential for various chemical reactions, including substitution, conjugate addition, carbo/metallocupration, and various other reactions.
2004·42citations·B. Lipshutz et al.·Organic Reactions
Organic Reactions
Stereoselective ring contraction diverts the Mitsunobu reaction of a 6-hydroxy-1,4-diazepan-2-one
Stereoselective ring contraction diverts the Mitsunobu reaction of a 6-hydroxy-1,4-diazepan-2-one to a ring-contracted 1,4-piperazine-2-one, with an unusual half-boat conformation determined by NMR analysis.
2003·4citations·S. Knapp et al.·Tetrahedron Letters
Tetrahedron Letters
A Concise Synthesis of (+)-Compactin Lactone by Asymmetric Dihydroxylation and Regioselective Cyclic Sulfite Opening Reactions
This study presents a concise, enantioselective synthesis of (+)-Compactin lactone 2 using Sharpless asymmetric dihydroxylation and regioselective nucleophilic opening of cyclic sulfite.
2002·20citations·R. Fernandes et al.·European Journal of Organic Chemistry
European Journal of Organic Chemistry