The preparation of ethyl 7‐chloro‐1‐cyclopropyl‐6‐fluoro‐1,4‐dihydro‐5‐methyl‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylate

doi:10.1002/JHET.5570280265

Paper

The preparation of ethyl 7‐chloro‐1‐cyclopropyl‐6‐fluoro‐1,4‐dihydro‐5‐methyl‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylate

Published Feb 1, 1991 · J. Kiely

Journal of Heterocyclic Chemistry

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Abstract

Ethyl 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid has been prepared by a route involving masking of the C 2,3 double bond through reduction, followed by regiosselective deprotonation of the C 5 position and methylation and then regeneration of the C 2,3 double bond via selenation, oxidation, and syn-elimination

Study Snapshot

Ethyl 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-4-oxo-1,8-naphthyridine-3-carboxylate is a novel synthetic intermediate for the production of ethyl

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

The preparation of ethyl 7‐chloro‐1‐cyclopropyl‐6‐fluoro‐1,4‐dihydro‐5‐methyl‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylate

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References

A general method for the preparation of 2‐substituted‐4‐oxo‐3‐quinolinecarboxylic acids

This method provides a general method for preparing new quinolone antiinfective analogs by reacting with 4-oxo-3-quinolinecarboxylic acid esters and 4-oxo-1,8-naphthyridine-3-carboxylic acid esters in the presence of

Synthesis and reactions of 7-substituted 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids as an antibacterial agent†

7-substituted 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids show potential as antibacterial agents, with potential for further development as a pharmaceutical agent.

Synthesis of fluorinated pyridines by the Balz-Schiemann reaction. An alternative route to enoxacin, a new antibacterial pyridonecarboxylic acid

The Balz-Schiemann reaction provides an alternative route to enoxacin, a new potential antibacterial agent, by fluorinating 2,6-disubstituted 3-aminopyridines.

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