Preparation of Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate

Paper

Preparation of Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate

Published 2009 · Jiang Cheng-jun

Chinese Journal of Pharmaceuticals

UNKNOWN SJR score

1

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0

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Abstract

Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate was synthesized from (S)-(-)-epichlorohydrin by ring-opening with sodium cyanide to form (S)-4-chloro-3-hydroxybutyronitrile,which was subjected to alcoholysis,protection of hydroxyl group with hexamethyl disilazane,cyanidation and then deprotection with hydrochloric acid. The total yield was 57%.

Study Snapshot

Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate can be synthesized from (S)-(-)-epichlorohydrin with a 57% yield, providing a promising intermediate for the synthesis of cyclopropanedioic acid

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Preparation of Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate

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References

Citations

Chemical and enzymatic approaches to the synthesis of optically pure ethyl (R)-4-cyano-3-hydroxybutanoate

This review highlights various synthetic strategies for optically active ethyl (R)-4-cyano-3-hydroxybutanoate, focusing on biocatalytic routes using halohydrin dehalogenase, nitrilase, carbonyl reductase, and lipas