Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate was synthesized from (S)-(-)-epichlorohydrin by ring-opening with sodium cyanide to form (S)-4-chloro-3-hydroxybutyronitrile,which was subjected to alcoholysis,protection of hydroxyl group with hexamethyl disilazane,cyanidation and then deprotection with hydrochloric acid. The total yield was 57%.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate can be synthesized from (S)-(-)-epichlorohydrin with a 57% yield, providing a promising intermediate for the synthesis of cyclopropanedioic acid

Paper

Preparation of Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate

References

Citations