N-Substituted derivatives of 1-ethylsulfonylpiperazine have been prepared following the announcement of 1-ethylsulfonyl-4-ethylpiperazine as an antishock agent. Derivatives representing possible oxidation products of the N'-ethyl group were prepared by introducing carboxymethyl and hydroxyethyl groups into 1-ethylsulfonylpiperazine. The latter compound was obtained from 1-benzyloxycarbonylpiperazine, and the benzyloxycarbonyl group was removed by catalytic hydrogenation and by nonhydrolytic cleavage without cleavage of the ethylsulfonyl group.

Oxidized derivatives of 1-ethylsulfonyl-4-ethylpiperazine show potential as antishock agents due to their potential oxidation products of the N'-ethyl group.

Paper

The preparation of oxidized derivatives of 1-ethylsulfonyl-4-ethylpiperazine.

References

Citations