Preparation and in vivo binding of [11C]carazolol, a radiotracer for the beta-adrenergic receptor.

doi:10.1016/0883-2897(92)90152-O

Paper

Preparation and in vivo binding of [11C]carazolol, a radiotracer for the beta-adrenergic receptor.

Published Jul 1, 1992 · Marc S. Berridge, E. H. Cassidy, A. H. Terris

International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology

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28

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Abstract

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Study Snapshot

[11C]carazolol, a radiotracer for beta-adrenergic receptors, shows potential as a radiopharmaceutical for positron tomography due to its biodistribution and specific receptor binding studies.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Preparation and in vivo binding of [11C]carazolol, a radiotracer for the beta-adrenergic receptor.

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References

Citations

Strategies towards in vivo imaging of active transglutaminase type 2 using positron emission tomography

In vivo imaging of active transglutaminase type 2 using positron emission tomography can help clarify its role in pathology and monitor its inhibition, aiding in drug development.

Synthesis and preliminary evaluation of (S)-[11C]-exaprolol, a novel β-adrenoceptor ligand for PET

(S)-[11C]-exaprolol is not a suitable -adrenoceptor ligand for PET, likely due to its in vivo affinity being in the nM range and its inhibition in lung, spleen, and erythrocytes due

Selective synthesis of [2-(11)C]2-iodopropane and [1-(11)C]iodoethane using the loop method by reacting methylmagnesium bromide with [11C]carbon dioxide.

The loop method effectively synthesizes radioactive [2-(11)C]2-iodopropane and [1-(11)C]iodoethane, with optimal conditions for producing radioactive [11C]radioligands.

Fluoro-A-85380 demonstrated no mutagenic properties in in vivo rat micronucleus and Ames tests.

Fluoro-A-85380 demonstrated no mutagenic properties in in vivo rat micronucleus and Ames tests.

Synthesis and evaluation of (S)-[18 F]-fluoroethylcarazolol for in vivo β-adrenoceptor imaging in the brain

(S)-[18F]-fluoroethylcarazolol is a high affinity ligand that specifically binds to cerebral -adrenoceptors in vivo and may be useful for -adrenoceptor imaging in the brain with PET