Process Improvement on the Synthesis of Ethyl 2-Aminoquinoline-3-carboxylate

Paper

Process Improvement on the Synthesis of Ethyl 2-Aminoquinoline-3-carboxylate

Published 2011 · Luo Yan-ping

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Abstract

2-Cyano-3-(2-nitrophenyl)-ethyl acrylate was converted to ethyl 2-aminoquinoline-3-carboxylate under reflux in acetic acid with iron powder as the reducing agent.The results showed that the optimum molar ratio of 2-cyano-3-(2-nitrophenyl)-ethyl acrylate to iron powder was 1 to 5,and the target compound was obtained in 94.7% yield with the structure confirmed by 1H NMR and GC-MS.

Study Snapshot

The optimal molar ratio of 2-cyano-3-(2-nitrophenyl)-ethyl acrylate to iron powder for ethyl 2-aminoquinoline-3-carboxylate synthesis is 1 to 5, yielding 94.7% of the target compound.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Process Improvement on the Synthesis of Ethyl 2-Aminoquinoline-3-carboxylate

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References

Citations

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-aminophosphonates containing 3,5-diphenyl-2-isoxazoline show promising antiviral activity against papaya ringspot virus, with two showing excellent activity, comparable to ningnanmycin and dufulin.

Discovery and identification of O, O-diethyl O-(4-(5-phenyl-4, 5-dihydroisoxazol-3-yl) phenyl) phosphorothioate (XP-1408) as a novel mode of action of organophosphorus insecticides

XP-1408 is a novel organophosphorus insecticide with a novel mode of action, offering a low-cost, less toxic alternative for pest control.