Process Improvement on the Synthesis of 1-Benzyloxycarbonyl-3-(t-butoxycarbonylamino)azetidine

Paper

Process Improvement on the Synthesis of 1-Benzyloxycarbonyl-3-(t-butoxycarbonylamino)azetidine

Published 2009 · Zhou Guo-chuan

Chinese Journal of Synthetic Chemistry

UNKNOWN SJR score

1

Citations

0

Influential Citations

Semantic Scholar

Abstract

1-Benzyloxycarbonyl-3-(t-butoxycarbonylamino)azetidine in total yield of 22.9% was synthesized by the reaction of ring-opening,cyclization,substitution,reduction and debenzylation from benzylamine and epichlorohydrin.The structure was determined by 1H NMR,13C NMR and MS.

Study Snapshot

This study improved the process for synthesizing 1-Benzyloxycarbonyl-3-(t-butoxycarbonylamino)azetidine from benzylamine and epichlorohydrin, leading to a 22.9% yield and improved product structure determination.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Process Improvement on the Synthesis of 1-Benzyloxycarbonyl-3-(t-butoxycarbonylamino)azetidine

Sign up to use Study Snapshot

References

Citations

A green and facile synthesis of an industrially important quaternary heterocyclic intermediates for baricitinib

This green and cost-effective method for synthesizing key quaternary heterocyclic intermediates for baricitinib is suitable for industrial production, using commercially available benzylamine and green oxidation reactions in microchannel reactors.