The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

doi:10.1016/0092-8674(92)90644-R

Paper

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Published Jun 26, 1992 · J. Momand, G. Zambetti, D. Olson

Cell

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Abstract

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In Vitro Study

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Study Snapshot

The mdm-2 oncogene product forms a tight complex with p53 protein and inhibits p53-mediated transactivation, potentially enhancing tumorigenic potential of cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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