DBU promoted Efficient Bioactive Synthesis of Novel 1-(2-methyl-1, 5-diphenyl-1H-pyrrol-3-yl) ethanone derivatives

doi:10.25303/2604rjce7285

Paper

DBU promoted Efficient Bioactive Synthesis of Novel 1-(2-methyl-1, 5-diphenyl-1H-pyrrol-3-yl) ethanone derivatives

Published Mar 25, 2022 · Setti S. Chinnayya, Gowd V. Suresh, B. Durga Rao

Research Journal of Chemistry and Environment

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Abstract

In an attempt to find new class of antibacterial agents, 1-(2-methyl-1,5-diphenyl-1H-pyrrol-3-yl)ethanone (4a –4j) were successfully synthesized from phenacyl bromide ,substituted aryl amine and aetylacetone in the presence of organic base such as DBU promoted in ethanol under reflux. The synthesized compounds were evaluated by spectroscopic techniques such as 1HNMR, 13CNMR and LCMS and elemental analysis. Derivatives were also evaluated for their antibacterial activity.

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DBU-promoted synthesis of novel 1-(2-methyl-1,5-diphenyl-1H-pyrrol-3-yl) ethanone derivatives demonstrates efficient bioactive synthesis and potential antibacterial activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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DBU promoted Efficient Bioactive Synthesis of Novel 1-(2-methyl-1, 5-diphenyl-1H-pyrrol-3-yl) ethanone derivatives

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