Pronounced anti-proliferative activity and tumor cell selectivity of 5-alkyl-2-amino-3-methylcarboxylate thiophenes.

doi:10.1016/j.ejmech.2017.03.044

Paper

DOI: 10.1016/j.ejmech.2017.03.044

Pronounced anti-proliferative activity and tumor cell selectivity of 5-alkyl-2-amino-3-methylcarboxylate thiophenes.

Published May 26, 2017 · Joice Thomas, Alenka Jecic, E. Vanstreels

European journal of medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

5-alkyl-2-amino-3-methylcarboxylate thiophenes show pronounced anti-proliferative activity and 500- to 1000-fold tumor cell selectivity, preferentially inhibiting the proliferation of specific tumor cell types.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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