Antiepileptic properties of novel 2-(substituted benzylidene)-7-(4-chlorophenyl)-5-(furan-2-yl)-2 H -thiazolo[3,2 -a ]pyrimidin-3(7 H )-one derivatives

doi:10.1016/J.JSCS.2012.07.018

Paper

Antiepileptic properties of novel 2-(substituted benzylidene)-7-(4-chlorophenyl)-5-(furan-2-yl)-2 H -thiazolo[3,2 -a ]pyrimidin-3(7 H )-one derivatives

Published Sep 1, 2016 · V. Karthick, T. Selvam, Vijayaraj Kumar Palanirajan

Journal of Saudi Chemical Society

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Abstract

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In Vitro Study

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Novel 2-(substituted benzylidene)-7-(4-chlorophenyl)-5-(furan-2-yl)-2 H -thiazolo[3,2 -a]pyrimidin-3(7 H)-one derivatives show antiepileptic

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Antiepileptic properties of novel 2-(substituted benzylidene)-7-(4-chlorophenyl)-5-(furan-2-yl)-2 H -thiazolo[3,2 -a ]pyrimidin-3(7 H )-one derivatives

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References

Synthesis of Novel 2,5‐Disubstituted 1,3,4‐Thiadiazoles for Their Potential Anticonvulsant Activity: Pharmacophoric Model Studies

Novel 2,5-disubstituted 1,3,4-thiadiazoles show significant anticonvulsant activity, with compound 19 showing the most activity in both electroshock seizure and subcutaneous pentylenetrtrazole models.

Targeting RSK: an overview of small molecule inhibitors.

RSK specific inhibitors show promise as anti-cancer agents, offering valuable insights into the molecular basis of cancer and offering potential therapeutic benefits.

Molecular modeling study and synthesis of novel pyrrolo[2,3-d]pyrimidines and pyrrolotriazolopyrimidines of expected antitumor and radioprotective activities.

Novel pyrrolo[2,3-d]pyrimidine derivatives show promising antitumor and radioprotective activities, with compound 10 showing significant radioprotective activity.

Synthesis of some new bioactive 3-amino-2-mercapto-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one derivatives.

New bioactive compounds synthesized from 3-amino-2-mercapto-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one show promising anti-inflammatory, CNS depressant, and antimicrobial activities

Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design.

N4-(2,6-dimethylphenyl) semicarbazones show wide spectrum anticonvulsant activity without neurotoxicity or hepatotoxicity, offering potential for new treatments for epilepsy.

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