Pharmacological properties of trimebutine and N-monodesmethyltrimebutine.

doi:10.1016/s0022-3565(24)38284-9

Paper

Pharmacological properties of trimebutine and N-monodesmethyltrimebutine.

Published Jun 1, 1999 · Francois Joseph Roman, Sandrine Lanet, Jacques Hamon

The Journal of pharmacology and experimental therapeutics

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46

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4

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Abstract

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In Vitro Study

Study Snapshot

Trimebutine and its metabolite, nor-TMB, show similar affinity for sodium channels and block glutamate release in the spinal cord, with a 17-fold more potent local anesthetic activity than lidocaine.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Pharmacological properties of trimebutine and N-monodesmethyltrimebutine.

References

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