Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1

doi:10.1038/s41598-020-62430-z

Paper

Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1

Published Apr 2, 2020 · Michala G Rolver, L. Elingaard-Larsen, A. Andersen

Scientific Reports

Q1 SJR score

43

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1

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Abstract

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In Vitro Study

Rigorous Journal

Study Snapshot

Pyrazinoylguanidine-type NHE1 inhibitors effectively inhibit cancer cell growth and survival in 3D culture, with their toxic effects being independent of NHE1.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1

References

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