The facile and convenient access by a conventional procedure in ethanol as solvent to a new series of succinyl-spaced pyrazoles including 1,4-bis[5-(trichloromethyl)-5-hydroxy-4,5-dihydro-1H-pyrazol-1-yl]butane-1,4-diones (64–82%) and the respective dehydrated derivatives as 1,4-bis[5-(trichloromethyl)-1H-pyrazol-1-yl]butane-1,4-diones in 57–82% yields, from the regioselective cyclocondensation reactions of 4-substituted 4-methoxy-1,1,1-trichloroalk-3-en-2-ones with succinic acid dihydrazide, where the 4-substituents are Me, Ph, 4-FC6H4, 4-ClC6H4, 4-NO2C6H4, 2-furyl, and 2-thienyl, is reported. J. Heterocyclic Chem., 2011.

This study presents a facile and convenient method for the synthesis of new succinyl-spaced pyrazoles, including 1,4-bis[5-(trichloromethyl)-5-hydroxy-4,5-dihydro-1H-pyrazol-1-yl]butane-1,4-

Paper

New succinyl-spaced pyrazoles: Regioselective synthesis of 1,4-bis[5-(trichloromethyl)-1H-pyrazol-1-yl]butane-1,4-diones

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