Binuclear pyrazoles. I. Synthesis and cytotoxic activity of 1,1'-dibenzyl and 1,1'-dihydroxymethyl 4,4'-bispyrazoles.

doi:10.1248/CPB.33.2535

Paper

Binuclear pyrazoles. I. Synthesis and cytotoxic activity of 1,1'-dibenzyl and 1,1'-dihydroxymethyl 4,4'-bispyrazoles.

Published Jun 25, 1985 · A. Cuadro, J. Elguero, P. Navarro

Chemical & pharmaceutical bulletin

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42

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Abstract

From 3, 3', 5, 5'-tetramethyl-4, 4'-bis-1 H-pyrazole, 3, 3', 5, 5'-tetramethyl-4, 4'-methylenebis-1 H-pyrazole and 4, 4'-methylenebis-1 H-pyrazole, the corresponding 1, 1'-dibenzyl and 1, 1'-dihydroxymethyl derivatives have been obtained. Benzylation of 1H-bispyrazoles was carried out by treatment with benzyl chloride under phase transfer conditions. Hydroxymethylation was done by treatment with 37% aqueous formaldehyde either in acidic or in neutral medium. All the products obtained have been evaluated as cytotoxic, and 1, 1'-dibenzyl-3, 3', 5, 5'-tetramethyl-4, 4'-bispyrazole is a powerful cytotoxic agent (ED50=7 μM).

Study Snapshot

1,1'-dibenzyl-3,3',5,5'-tetramethyl-4,4'-bispyrazole is a powerful cytotoxic agent with an ED50 of 7 M.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Binuclear pyrazoles. I. Synthesis and cytotoxic activity of 1,1'-dibenzyl and 1,1'-dihydroxymethyl 4,4'-bispyrazoles.

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References

Citations

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