Paper
Pyrazolo[1,5-a]pyridines as p38 kinase inhibitors.
Published Sep 23, 2005 · K. Stevens, D. Jung, M. Alberti
Organic letters
Q1 SJR score
69
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Influential Citations
Abstract
[reaction: see text] A convergent synthesis of substituted pyrazolo[1,5-a]pyridines has been achieved either via a regioselective [3 + 2] cycloaddition of N-aminopyridines with alkynes or by thermal cyclization of disubstituted azirines. Subsequent palladium-catalyzed introduction of pyridines or de novo synthesis of pyrimidines affords inhibitors of p38 kinase.
Study Snapshot
Substituted pyrazolo[1,5-a]pyridines can be synthesized and then used as p38 kinase inhibitors by palladium-catalyzed introduction of pyridines or de novo synthesis of pyrimidines.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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Organic letters
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