Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones. II. Synthesis and in vitro antimicrobial evaluation.

Paper

Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones. II. Synthesis and in vitro antimicrobial evaluation.

Published Jun 1, 1996 · F. Bruni, S. Selleri, A. Costanzo

Farmaco

UNKNOWN SJR score

5

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0

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Abstract

A series of Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones (4a-p) was prepared by a simple synthetic procedure based on the reaction of hydroxylamine or methoxyamine with 2,3-substituted ethyl 7-dimethylaminovinyl pyrazolo[1,5-a]pyrimidin-6-carboxylates (3a-p). The antimicrobial activity of the obtained compounds was evaluated on a series of standard strains of Gram positive, Gram negative bacteria and fungi. None of the tested compounds showed significant activity.

In Vitro Study

Study Snapshot

Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones show no significant antimicrobial activity against standard strains of Gram positive, Gram negative bacteria and fungi.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones. II. Synthesis and in vitro antimicrobial evaluation.

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References

Citations

Anti-Inflammatory Activity of Pyrazolo[1,5-a]quinazolines

Pyrazolo[1,5-a]quinazolines show potential as lead anti-inflammatory drugs targeting MAPKs, with compounds 13i and 16 showing the highest potency.

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This paper surveys the development of synthetic routes for three heterocyclic ring systems (5-6-6) from 1983-2006, focusing on structural similarities and cycl[3.2.2]azines.

Chapter 6.2 Six-membered ring systems

Diazines and benzo derivatives are key structural elements in many natural and synthetic compounds, and recent advances in synthesis offer convenient access to diazine-based carbodiimides.