Pyrazolopyridines II: synthesis and antibacterial screening of 6-aryl-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acids

doi:10.14233/AJCHEM.2014.15918

Paper

Pyrazolopyridines II: synthesis and antibacterial screening of 6-aryl-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acids

Published May 10, 2014 · T. Maqbool, A. Nazeer, M. N. Khan

Asian Journal of Chemistry

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20

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Abstract

5-Amino-3-methyl-1-phenyl-1H-pyrazole was prepared to react with various aromatic aldehydes and pyruvic acid to afford 6-aryl-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carbxylic acids. The prepared compounds were characterized by Mass, IR, 1H, 13C NMR spectra and CHN analysis data. Various 6-aryl-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carbxylic acids synthesized during this work were also evaluated for their antibacterial activities. Some of these compounds were found to be good antibacterial agents.

Study Snapshot

6-aryl-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acids show potential as effective antibacterial agents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Pyrazolopyridines II: synthesis and antibacterial screening of 6-aryl-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acids

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References

Citations

Synthesis of Pyrazolo[3,4-b]pyridine Derivatives and Their In-Vitro and In-Silico Antidiabetic Activities.

Pyrazolo[3,4-b]pyridine derivatives show significant antidiabetic activity, with 3c and 4c showing the most activity, making them promising candidates for further in-vivo studies in mice models.

Tailor‐Made Pyrazolopyridines and Fused Pyrazolopyridines: Recent Updates toward Sustainable Synthesis

Sustainable one-pot reactions for synthesizing pyrazolopyridine systems have been developed, offering potential for developing new, eco-friendly drugs.

Synthesis of tetrahydropyrazolopyridines derivatives via novel functionalized graphene oxide reinforced aminated dextrin (FGO@dextrin) polymer nanocomposite

The FGO@dextrin polymer nanocomposite is a versatile, biocompatible catalyst for synthesis of tetrahydropyrazolopyridine derivatives with high yields (90-98%) at room temperature, with potential for seven consecutive cycles without significant activity loss.

Recent advances in the synthesis of pyrazole scaffolds via nanoparticles: A review

Nanoparticles have shown potential in the synthesis of various pyrazole derivatives, which possess significant biological and pharmacological activities.

Iron(III)chloride induced synthesis of pyrazolopyridines & quinolines

This study presents a simple, straightforward method for synthesis of pyrazolopyridines and quinolines using iron(III)chloride, offering high compatibility and excellent yields.