Pyridazinoquinoxalines. 10. Synthesis and antitubercular activity of 3-hydrazino derivatives of pyridazino [3,4-b] quinoxaline

doi:10.1007/BF00764619

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Pyridazinoquinoxalines. 10. Synthesis and antitubercular activity of 3-hydrazino derivatives of pyridazino [3,4-b] quinoxaline

Published Nov 1, 1989 · T. V. Kartseva, G. S. Predvoditeleva, O. Oleshko

Pharmaceutical Chemistry Journal

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Abstract

It was shown in the preceding publications that pyridazinoquinoxalines alkylated with a butyl radical at the nitrogen atom of the pyridazine ring have high tuberculostatic activity [2, 3]. Exhaustive alkylation, i.e., preparation of quaternary salts of pyridazinoquinoline, leads to increased tuberculostatic activity. Of these compounds, the quaternary salts of 3hydrazino derivatives of pyridazinoquinoxaline have the highest antitubercular activity [4]. On the basis of the above facts and in continuation of our efforts to reveal the relationship between the chemical structure and the biological activity~ we synthesized new 3-hydrazino derivatives of alkyl-substituted pyridazino[3,4-b] quinoxaline [I].

Study Snapshot

New 3-hydrazino derivatives of alkyl-substituted pyridazino[3,4-b] quinoxaline show high antitubercular activity, with quaternary salts showing the highest antitubercular activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Pyridazinoquinoxalines. 10. Synthesis and antitubercular activity of 3-hydrazino derivatives of pyridazino [3,4-b] quinoxaline

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