Paper
Pyrimidinium Ylides. Part 10. Synthesis of New Pyrrolo[1,2‐C]pyrimidines by the Reaction of 4‐(2‐Furyl)‐ and 4‐(2‐Thienyl)pyrimidinium Ylides with Symmetrically Substituted Alkynes.
Published Dec 17, 2002 · P. C. Iuhas, F. Georgescu, E. Georgescu
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Abstract
The synthesis of some new furyl- and thienyl-substituted pyrrolo[1,2-c]-pyrimidine derivatives by the 1,3-dipolar cycloaddition reactions of some 4-(2-furyl)- and 4-(2-thienyl)pyrimidinium ylides with symmetrically substituted acetylenes is presented. The 4-(2-furyl)- and 4-(2-thienyl)-pyrimidinium ylides were generated in situ from the corresponding pyrimidinium quaternary salts in the presence of triethylamine or an epoxide. The structures of these new furyl-and thienyl-substituted pyrrolo[1,2-c]-pyrimidine derivatives were confirmed by IR and 1 H-NMR spectroscopy.
This study presents the synthesis of new furyl- and thienyl-substituted pyrrolo[1,2-c]-pyrimidine derivatives by the 1,3-dipolar cycloaddition reactions of 4-(2-furyl)- and 4-(2-thienyl
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