New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis.

doi:10.1016/j.bioorg.2021.104807

Paper

New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis.

Published Mar 5, 2021 · Nawaf A. Alsaif, Mohammed A. Dahab, M. Alanazi

Bioorganic chemistry

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72

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Abstract

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In Vitro Study

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Study Snapshot

New quinoxaline derivatives show promising anti-cancer and apoptotic activities, with compound 25d inducing apoptosis in HepG2 cells and showing promising VEGFR-2 inhibitory activities.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis.

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References

Citations

Integrated in silico and in vitro exploration of the anti-VEGFR-2 activities of a semisynthetic xanthine alkaloid inhibiting breast cancer

T-1-NBAB shows potential as a strong anticancer agent and anti-angiogenic agent by effectively inhibiting VEGFR-2 and inducing early and late apoptosis in breast cancer cells.

An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024)

Quinoxaline derivatives show potential in treating various diseases, including cancer and infectious diseases, with recent advancements in their bioactivity and drug-like properties.

Design and synthesis of new nicotinamides as immunomodulatory VEGFR-2 inhibitors and apoptosis inducers.

Compound 16c shows strong anti-VEGFR-2 potential and apoptosis inducing effects, making it a promising candidate for creating a novel antiangiogenic lead anticancer medication.

Targeting Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2): Latest Insights on Synthetic Strategies

Recent advances in the development of novel VEGFR-2 inhibitors show promise in synthesis and antiproliferative activities, addressing challenges like drug resistance and adverse side effects.

Recent updates on potential of VEGFR-2 small-molecule inhibitors as anticancer agents

Recent updates on VEGFR-2 inhibitors show potential for developing safer and more effective anticancer agents, aiding in the discovery of new lead molecules for various cancers.

A novel biological antibacterial polyvinyl alcohol/polyionic liquid hydrogel for wound dressing.

The novel PVA/PIL hydrogel shows promising antibacterial effects against E.coli and S.aureus, with potential for wound dressing due to its high water content, excellent water absorption, and biocompatibility.