A radical mediated C-H functionalization of 3,6-dichloropyridazine using primary alcohols, t-BuOOH, and TiCl3 to access alkoxy pyridazines is described. This transformation is conducted open to air and on gram scale. A subsequent cyclization step can then be employed to efficiently access diversely substituted tetrahydropyridopyridazines with multiple functional handles.

This radical-mediated C-H functionalization of 3,6-dichloropyridazine efficiently accesses diversely substituted tetrahydropyridopyridazines with multiple functional handles, enabling efficient synthesis of novel compounds.

Paper

Radical mediated C-H functionalization of 3,6-dichloropyridazine: efficient access to novel tetrahydropyridopyridazines.

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