Radical-Mediated Difunctionalization of Styrenes

doi:10.1055/s-0039-1690987

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Radical-Mediated Difunctionalization of Styrenes

Published Oct 10, 2019 · Xiazhen Bao, Jun Li, Wei‐Qun Jiang

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Abstract

Abstract Styrene, an extremely important compound in the chemical industry, is mainly produced by the dehydrogenation or oxidative dehydrogenation of ethylbenzene. Transformation of this raw organic material to more useful fine organic chemicals is a very significant topic. Recently, the radical difunctionalization of styrene has become a powerful and efficient tool for organic synthesis. This strategy can introduce two substituents into a styrene molecule in one step via addition to the C=C bond, enhancing the molecular complexity in a single operation with good selectivity and wide functional group compatibility. 1 Introduction 2 C-Centered Radicals 3 CF3 and Other Polyfluoroalkyl Radicals 4 N-Centered Radicals 5 P-Centered Radicals 6 O-Centered Radicals 7 S-Centered Radicals 8 Other-Atom-Centered Radicals 9 Conclusion and Perspective

Study Snapshot

Radical difunctionalization of styrenes can efficiently introduce two substituents in one step, enhancing molecular complexity and allowing for wide functional group compatibility in organic synthesis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Radical-Mediated Difunctionalization of Styrenes

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