The reaction of 4-Amino-5-aminomethyl-2-methylpyrimidine with amidine salts

doi:10.1071/CH9731599

Paper

The reaction of 4-Amino-5-aminomethyl-2-methylpyrimidine with amidine salts

Published 1973 · R. F. Evans, A. V. Robertson

Australian Journal of Chemistry

Q3 SJR score

4

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

Treatment of 4-amino-5-aminomethyl-2-methylpyrimidine with formamidine salts yields not the expected dihydropyrimidopyrimidine, but rather its ring-opened hydrate, 4-amino-5-formamidomethyl-2-methylpyrimidine. Other workers had previously prepared the latter compound by other methods, but had assigned a wrong structure. The present structure determination is based mainly on i.r., N.M.R., and mass spectrometric analysis, as well as examination of the corresponding acetamido series. Mass spectra include a noteworthy fragmentation process, expulsion of neutral, even-electron NH.

Study Snapshot

The reaction of 4-amino-5-aminomethyl-2-methylpyrimidine with formamidine salts yields 4-amino-5-formamidomethyl-2-methylpyrimidine, a ring-opened hydrate with a correct structure determined by ir, NMR, and mass

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

The reaction of 4-Amino-5-aminomethyl-2-methylpyrimidine with amidine salts

References

Citations

Vitamins, 6. B Vitamins

Vitamin B6 is a crucial vitamin for maintaining normal metabolism and preventing deficiency symptoms.

Development, scope and mechanisms of multicomponent reactions of asymmetric electron-deficient alkynes with amines and formaldehyde.

Catalyst-free multicomponent reaction of electron-deficient alkynes, aliphatic amines, and formaldehyde provides high regioselectivity and excellent yields for polysubstituted pyrimidine derivatives.

A New Convergent Synthesis of Thiamine Hydrochloride

Thiamine hydrochloride (1a) can be synthesized in excellent yield by condensation of 3-mercapto-4-oxopentyl acetate (5a) with 3, 4-dihydro-7-methylpyrimido[4, 5-d]pyrimidine (4) in formic acid.