The reaction of N-(5-chloropyridin-2-yl)-N′N′-dialkylthioureas with phenacyl bromides yields trisubstituted thiazoles via a 1,3-pyridyl shift; the X-ray crystal structure of one of these, 5-(5-chloropyridin-2-yl)-2-diethylamino-4-phenylthiazole, has been determined.

This study demonstrates a new thiazole synthesis and crystal structure determination, revealing a 1,3-pyridyl shift in the reaction of 5-chloropyridin-2-yl-thioureas with phenacyl bromides.

Journal of The Chemical Society, Chemical Communications

Reaction of 5-chloropyridin-2-yl-thioureas with phenacyl bromides: a new thiazole synthesis. X-Ray crystal structure of 5-(5-chloropyridin-2-yl)-2-diethylamino-4-phenylthiazole

Paper

Reaction of 5-chloropyridin-2-yl-thioureas with phenacyl bromides: a new thiazole synthesis. X-Ray crystal structure of 5-(5-chloropyridin-2-yl)-2-diethylamino-4-phenylthiazole

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