Reaction of tetrakis(dimethylamino)ethylene with CF2Br2 in the presence of secondary amines, formation of N-trifluoromethyl-dialkylamines

doi:10.1016/S0022-1139(00)80138-4

Paper

Reaction of tetrakis(dimethylamino)ethylene with CF2Br2 in the presence of secondary amines, formation of N-trifluoromethyl-dialkylamines

Published Apr 15, 1991 · G. Pawelke

Journal of Fluorine Chemistry

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Abstract

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Study Snapshot

N-trifluoromethyl-dialkylamines can be synthesized from secondary amines using tetrakis(dimethylamino)ethylene/CF2Br2/(CH2 )4 SO2, with moderate yields and characterized by elemental analyses and NMR spec

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Reaction of tetrakis(dimethylamino)ethylene with CF2Br2 in the presence of secondary amines, formation of N-trifluoromethyl-dialkylamines

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References

Dialkyl-∝,∝-difluorobenzylamines and dialkyl(trifluoromethyl)-amines - novel fluorinating reagents

Dialkyl-,-difluorobenzylamines and dialkyl(trifluoromethyl)-amines show promising potential as fluorinating reagents for replacing hydroxyl groups in alcohols and carboxylic acids.

Reaction of tertiary formamides with sulphur tetrafluoride. Direct synthesis of (trifluoromethyl)amines

Sulphur tetrafluoride treatment of tertiary formamides with potassium fluoride leads to direct conversion of formyl groups to trifluoromethyl groups, yielding various (trifluoromethyl)amines.

Citations

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This one-pot method efficiently synthesizes trifluoromethylated amines at room temperature using the bench-stable (Me4N)SCF3 reagent and AgF, making it ideal for late-stage introduction of trifluoromethyl groups on pharmaceutically relevant drug molecules.

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