Paper
Three-Component Reactions of α-Amino Acids, p-Quinone Monoacetals and Diarylphosphine Oxides to Selectively Afford 3-(Diarylphosphinyl)anilides and N-Aryl-2-Diarylphosphinylpyrrolidines.
Published Mar 30, 2020 · Xin Wang, Can Zhang, Ruwei Shen
The Journal of organic chemistry
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Abstract
The three-component reactions of α-amino acids, p-quinone monoacetals (or p-quinol ethers) and diarylphosphine oxides have been developed for the synthesis of 3-(diarylphosphinyl) anilides and N-aryl-2-diarylphosphinylpyrrolidines. The transformations may involve the in situ generation of conjugated azomethine ylides or 2-azaallyl anion species from the reaction of α-amino acids and p-quinone monoacetals, which are further trapped by diarylphosphine oxides.
This study developed a three-component reaction for selectively synthesizing 3-(diarylphosphinyl) anilides and N-aryl-2-diarylphosphinylpyrrolidines using -amino acids, p-quinone monoacetal
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