Reactions of methyl 3,3,3-trifluoro-2-(pyridin-2-ylimino)propanoates with such nucleophiles and 1,3-binucleophiles as methanol, p-toluidine, phenylhydrazine, diethyl phosphonate, 2-aminobut-2-enenitrile, benzamidine, and 4,5-dihydro-1,3-thiazol-2-amine led to the formation of various acyclic 2-substituted methyl 3,3,3-trifluoro-2-(pyridin-2-ylamino)propanoates and trifluoromethyl-containing heterocyclic N-substituted 2-aminopyridine derivatives: 4,5-dihydro-1H-pyrroles, 4,5-dihydro-1H-imidazol-5-ones, and 2,3-dihydro-6Himidazo[2,1-b][1,3]thiazol-5-ones.

This study demonstrates the potential of methyl 3,3,3-trifluoro-2-(pyridin-2-ylimino)-propanoates as a versatile nucleophile for a variety of reactions, resulting in various acyclic 2-substituted derivatives and trifluor

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Reactions of methyl 3,3,3-trifluoro-2-(pyridin-2-ylimino)-propanoates with mono- and difunctional nucleophiles

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