Reactions of N-hydroxysuccinimide esters of N-alkoxycarbonyl-α-amino acids with active methylene compounds. Synthesis of 3-substituted tetramic acids

doi:10.1039/CC9960001323

Paper

DOI: 10.1039/CC9960001323

Reactions of N-hydroxysuccinimide esters of N-alkoxycarbonyl-α-amino acids with active methylene compounds. Synthesis of 3-substituted tetramic acids

Published 1996 · A. Detsi, J. Markopoulos, O. Igglessi-Markopoulou

Chemical Communications

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Abstract

The N-hydroxysuccinimide esters of N-alkoxycarbonyl-α-amino acids react with active methylene compounds (cyanoacetic esters, malonic and acyl acetic esters), under basic conditions, to produce 3-substituted N-alkoxycarbonyl tetramic acids; in the case of the N-hydroxysuccinimide esters derived from L-aminoacids, the corresponding optically active tetramic acids are obtained.

Study Snapshot

N-hydroxysuccinimide esters of N-alkoxycarbonyl--amino acids react with active methylene compounds to produce 3-substituted N-alkoxycarbonyl tetramic acids under basic conditions.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis, biological evaluation and structure-activity relationships of 5-arylidene tetramic acids with antibacterial activity against methicillin-resistant Staphylococcus aureus.

Novel 3-substuted 5-arylidene tetramic acids show moderate to high antibacterial activity against methicillin-resistant Staphylococcus aureus, with no human cell toxicity or hemolytic activity.

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