Paper
Reactivity and properties of bis(chlorodifluoroacetyl) peroxide generated in situ from chlorodifluoroacetic anhydride for chlorodifluoromethylation reactions.
Published Oct 4, 2018 · S. Kawamura, C. Henderson, Yuma Aoki
Chemical communications
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Abstract
We developed a practical chlorodifluoromethylation reaction mediated by diacyl peroxide generated in situ from chlorodifluoroacetic anhydride. Allylic and amino-chlorodifluoromethylations of alkenes proceeded well with the combination of this reagent, Cu(ii) catalyst and a pyridine additive. Carbo- and aromatic chlorodifluoromethylations proceeded under metal-free conditions.
This study developed a practical chlorodifluoromethylation reaction using diacyl peroxide generated in situ from chlorodifluoroacetic anhydride, enabling efficient allylic and amino-chlorodifluoromethylations of alkenes under metal-free conditions.
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