The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cells.

doi:10.1016/j.clim.2009.06.002

Paper

DOI: 10.1016/j.clim.2009.06.002

The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cells.

Published Oct 1, 2009 · Wen-Hai Shao, Yuxuan Zhen, R. Eisenberg

Clinical immunology

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Abstract

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In Vitro Study

Study Snapshot

The Mer receptor tyrosine kinase plays a crucial role in immune response modulation by mediating apoptotic cell phagocytic activity and regulating macrophage and DC cytokine production.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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A Defect in Marco Expression Contributes to Systemic Lupus Erythematosus Development via Failure to Clear Apoptotic Cells1

Reduced expression of the innate scavenger receptor Marco contributes to systemic lupus erythematosus development by causing a failure to clear apoptotic cells, potentially leading to the production of anti-dsDNA antibodies.

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Citations

DOI: 10.3389/fimmu.2024.1380628

Differential regulation of lung homeostasis and silicosis by the TAM receptors MerTk and Axl

MerTk is critical for maintaining lung homeostasis, while Axl plays a role in regulating silica-induced inflammation, potentially impacting understanding of pulmonary inflammatory disorders and developing new therapies.

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Trimethyltin chloride induces apoptosis and DNA damage via ROS/NF-κB in grass carp liver cells causing immune dysfunction.

TMT induces apoptosis and DNA damage in grass carp liver cells, leading to immune dysfunction, contributing to the environmental risks of fungicides and plastic stabilizers.

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Apoptotic cell fragments locally activate tingible body macrophages in the germinal center

Tingible body macrophages (TBMs) in lymphoid follicles clear apoptotic debris and prevent antibody-mediated autoimmune diseases by activating and maturing from follicular macrophages.

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The Akt–mTORC1 pathway mediates Axl receptor tyrosine kinase‐induced mesangial cell proliferation

Axl receptor tyrosine kinase promotes mesangial cell proliferation and phagocytic activity in kidney diseases by activating NFB and mTORC1.

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Immuno-oncology: are TAM receptors in glioblastoma friends or foes?

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TAM receptors: A phosphatidylserine receptor family and its implications in viral infections.

TAM receptors play a proviral role in viral infections, but understanding this pathway may help reduce viral replication and pathogenicity.

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