Recyclization of methyl 1-aryl-3-cinnamoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates in reaction with monosubstituted hydrazines

doi:10.3998/ARK.5550190.P009.068

Paper

Recyclization of methyl 1-aryl-3-cinnamoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates in reaction with monosubstituted hydrazines

Published Jun 11, 2015 · V. Filimonov, P. Silaichev, M. Kodess

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Abstract

Methyl 1-aryl-3-cinnamoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates react with phenyl- hydrazine or benzylhydrazine to give the corresponding methyl 1-(phenyl or benzyl)-5- (arylcarbamoyl)-4-cinnamoyl-1H-pyrazole-3-carboxylates in good yields. The structures of the compounds obtained were proved by 1D 1 H, 13 C and 2D NMR experiments.

Study Snapshot

Methyl 1-(phenyl or benzyl)-5- (arylcarbamoyl)-4-cinnamoyl-1H-pyrazole-3-carboxylates can be efficiently recycled by reacting with phenyl-hydrazine or benzyl

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Recyclization of methyl 1-aryl-3-cinnamoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates in reaction with monosubstituted hydrazines

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References

Citations

A clean synthesis of 2,5-dihydro-1H-pyrrole-2-carboxylates under catalyst-free and solvent-free conditions: cytotoxicity and molecular docking studies

This method allows for the quick and efficient synthesis of 2,5-dihydro-1H-pyrrole-2-carboxylates, with one showing good cytotoxic activity against cancer cell lines.