Redesign of a short-chain dehydrogenase/reductase for asymmetric synthesis of ethyl (R)-2-hydroxy-4-phenylbutanoate based on per-residue free energy decomposition and sequence conservatism analysis

doi:10.1016/J.GRESC.2020.09.003

Paper

Redesign of a short-chain dehydrogenase/reductase for asymmetric synthesis of ethyl (R)-2-hydroxy-4-phenylbutanoate based on per-residue free energy decomposition and sequence conservatism analysis

Published Sep 26, 2020 · Bing-Mei Su, Lian Xu, Xinqi Xu

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Abstract

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Study Snapshot

This study successfully designed a biocatalyst with high enantioselectivity for asymmetric synthesis of ethyl (R)-2-hydroxyl-4-phenylbutanoate using per-residue free energy decomposition and sequence conservatism analysis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Redesign of a short-chain dehydrogenase/reductase for asymmetric synthesis of ethyl (R)-2-hydroxy-4-phenylbutanoate based on per-residue free energy decomposition and sequence conservatism analysis

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