Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase

doi:10.1016/j.matbio.2011.01.002

Paper

Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase

Published Apr 1, 2011 · C. Clarkin, S. Allen, C. Wheeler-Jones

Matrix Biology

Q1 SJR score

24

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0

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Abstract

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In Vitro Study

Study Snapshot

4-methylumbelliferone reduces hyaluronan and sGAG production in chick limb bud culture, potentially targeting UDP-glucose dehydrogenase for potential clinical success.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase

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