Reduction of collagen production in keloid fibroblast cultures by ethyl-3,4-dihydroxybenzoate. Inhibition of prolyl hydroxylase activity as a mechanism of action.

doi:10.1016/s0021-9258(18)48093-3

Paper

Reduction of collagen production in keloid fibroblast cultures by ethyl-3,4-dihydroxybenzoate. Inhibition of prolyl hydroxylase activity as a mechanism of action.

Published Jul 5, 1987 · Tetsu Sasaki, Kari MajamaaS, Jouni Uittog

The Journal of biological chemistry

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83

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4

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Highly Cited

Study Snapshot

Ethyl-3,4-dihydroxybenzoate effectively reduces collagen production in fibroblast cultures by inhibiting the post-translational synthesis of 4-hydroxyproline, potentially benefiting fibrotic diseases.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Reduction of collagen production in keloid fibroblast cultures by ethyl-3,4-dihydroxybenzoate. Inhibition of prolyl hydroxylase activity as a mechanism of action.

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