Regiospecific synthesis of 1,5-disubstituted-1H-pyrazoles containing differentiated 3,4-dicarboxylic acid esters via Suzuki coupling of the corresponding 5-trifluoromethane sulfonates

doi:10.1016/J.TET.2006.11.053

Paper

Regiospecific synthesis of 1,5-disubstituted-1H-pyrazoles containing differentiated 3,4-dicarboxylic acid esters via Suzuki coupling of the corresponding 5-trifluoromethane sulfonates

Published Jan 29, 2007 · P. Dragovich, Thomas M. Bertolini, B. Ayida

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Abstract

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Study Snapshot

This study presents a regiospecific method for preparing 1,5-disubstituted-1H-pyrazoles with differentiated ester moieties at the 3- and 4-positions, using palladium-mediated Suzuki coupling with various boronic acids.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Regiospecific synthesis of 1,5-disubstituted-1H-pyrazoles containing differentiated 3,4-dicarboxylic acid esters via Suzuki coupling of the corresponding 5-trifluoromethane sulfonates

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