Systemic pretreatment of rats with diphenylhydantoin (DPH) or its addition into an in vitro assay increases 5α-reduction of testosterone by the oral mucosa. Enzyme kinetic studies showed that DPH binds to the enzyme and probably activates it by an allosteric mechanism.

Diphenylhydantoin activates the enzyme 4-3-ketosteroid-5-A ring reductase in oral mucosa, increasing testosterone 5-reduction by an allosteric mechanism.

Journal of Dental Research

Cellular Regulation of the Metabolism of Androgens in Rat Oral Mucosa. III. Activation of Δ4-3-ketosteroid-5α-A Ring Reductase Enzyme System by 5,5-Diphenylhydantoin

Paper

Cellular Regulation of the Metabolism of Androgens in Rat Oral Mucosa. III. Activation of Δ4-3-ketosteroid-5α-A Ring Reductase Enzyme System by 5,5-Diphenylhydantoin

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