[Experimental research on the antisecretory and antiulcer activity of (+/-) 15 alpha-OH-11-deoxyprostaglandin E1].

Paper

[Experimental research on the antisecretory and antiulcer activity of (+/-) 15 alpha-OH-11-deoxyprostaglandin E1].

Published 1988 · Z. A. Atare, Iu. G. Markov, Ia F Freĭmanis

Farmakologiia i toksikologiia

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Abstract

(+/-) 15 alpha-OH-11-deoxyprostaglandin E1 was found to possess a pronounced antisecretory activity at stimulation of gastric secretion in cats with pentagastrin. In rats the compound exerted the protective effect of cells of the gastric mucosa, especially on indomethacin and stress models of ulcerogenesis. The cytoprotective effect of the compound seemed to be related to its action on secretion of mucus as well as to its stimulation of zinc accumulation in cells that stabilized cell membranes and suppressed the secretory activity of mast cells.

Non-RCTAnimal Study

Study Snapshot

(+/-) 15 alpha-OH-11-deoxyprostaglandin E1 exhibits antisecretory and antiulcer properties, potentially due to its effect on mucus secretion and its stimulation of zinc accumulation in cells, which stabilizes membranes and suppresses mast cell secretion.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

[Experimental research on the antisecretory and antiulcer activity of (+/-) 15 alpha-OH-11-deoxyprostaglandin E1].

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