: (+/-) 15 alpha-OH-11-deoxyprostaglandin E1 was found to possess a pronounced antisecretory activity at stimulation of gastric secretion in cats with pentagastrin. In rats the compound exerted the protective effect of cells of the gastric mucosa, especially on indomethacin and stress models of ulcerogenesis. The cytoprotective effect of the compound seemed to be related to its action on secretion of mucus as well as to its stimulation of zinc accumulation in cells that stabilized cell membranes and suppressed the secretory activity of mast cells.

(+/-) 15 alpha-OH-11-deoxyprostaglandin E1 exhibits antisecretory and antiulcer properties, potentially due to its action on mucus secretion and stimulation of zinc accumulation in cells, which stabilizes membranes and suppresses mast cell secretion.

Paper

[Experimental research on the antisecretory and antiulcer activity of (+/-) 15 alpha-OH-11-deoxyprostaglandin E1].

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