A group of ethyl 2-methylimidazo[1,2-a]pyrimidine-3-carboxylates were prepared by reaction of ethyl 2-chloroacetoacetate with some 2-aminopyrimidines. These ethyl esters were then converted into the corresponding carboxylic acids via alkaline hydrolysis. The acids so obtained were evaluated for antiinflammatory, analgesic, antipyretic and ulcerogenic activities.

The ethyl 2-methylimidazo[1,2-a]pyrimidine-3-carboxylic acids show potential antiinflammatory, analgesic, antipyretic, and ulcerogenic activities.

Paper

Research on heterocyclic compounds. XVII. 2-Methylimidazo[1,2-a]pyrimidine-3-carboxylic acids.

References

Citations