Paper
Residues of beclotiamine, a new coccidiostat, in chicken tissues and egg yolks, and its toxicity to chickens.
Published Sep 1, 1971 · M. Yamazaki, M. Sasaki, T. Matsuzawa
Poultry science
3
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Abstract
Abstract BECLOTIAMINE, 1 a thiamine analogue having a chloroethyl group in place of the hydroxyethyl group in the thiazole moiety, was reported prophylactically effective against coccidiosis in chickens (Inoue et al., 1967; Taniguchi et al., 1969; Matsuzawa et al., 1970). Coccidiosis may be controlled by the incorporation of Beclotiamine naphthalene disulfonate (NDS) in finished feeds at the 0.0125% level. The present experiment was undertaken to determine the Beclotiamine residues in tissues and eggs following continuous feeding of Beclotiamine to chickens or laying hens. For the purpose, a sensitive method for the estimation of Beclotiamine in tissues and eggs was established. The effect of Beclotiamine on the total thiamine levels in the liver and on performance of the chickens was also examined. ANALYTICAL METHODS Beclotiamine determination in tissues and egg yolks. Extraction and cleanup (a) Tissue (muscle and liver). Beclotiamine was extracted from tissues with 0.1 N hydrochloric acid, and purified together with…
Beclotiamine residues in chicken tissues and egg yolks are not toxic to chickens, and its incorporation in feed at 0.0125% effectively controls coccidiosis in chickens.
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